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Late Breakers

Top 5 Industry Updates

DecisionDx-SCC Improves Risk Stratification and Treatment Guidance in High-Risk Cutaneous SCC

Two new studies show DecisionDx-SCC improves risk prediction and treatment guidance in high-risk cutaneous squamous cell carcinoma, outperforming traditional staging systems.

Descriptive Analysis Further Supports Long-term Safety of Treating Chronic Diseases with Upadacitinib

A new study reports on the long-term safety of upadacitinib in seven chronic diseases.

Industry Information

DUPIXENT® (dupilumab) APPROVED FOR ANOTHER NEW INDICATION

Learn about the new approval for DUPIXENT

Novel Risk Score Predicts Post-transplant Recurrence in Perihilar Cholangiocarcinoma

A new study documents the validation and application of a risk score for predicting post-transplant recurrence in perihilar cholangiocarcinoma.

Industry Information

New Data Show 40-Gene Expression Profile (DecisionDx®-SCC) Identifies Cutaneous Squamous Cell Carcinoma Patients Most Likely to Benefit from Adjuvant Radiation Therapy

Study results demonstrate that DecisionDx-SCC can identify high-risk cutaneous squamous cell carcinoma patients who are most likely to benefit from adjuvant radiation therapy.

AI Assistance Improves GI Precancerous Lesion Detection Rates

A new study concludes that artificial intelligence systems have the potential to significantly improve the detection rates of precancerous conditions, especially among endoscopists with less experience.

Educational Video Intervention Fails to Improve Bowel Preparation for Colonoscopy Versus Written Instructions

A new study reports that providing inflammatory bowel disease (IBD) patients with a brief educational video intervention did not improve bowel preparation before colonoscopy.

Risk Levels for Hematologic, Solid Organ Cancers Increased Among Systemic Sclerosis Patients

A new study reports that the risks for both hematologic and solid organ cancers are significantly increased among patients with systemic sclerosis, with variation according to auto-antibody status.

Telerehabilitation Improves Disease Activity, Function, and Mobility in Axial Spondyloarthritis

A new study concludes that telerehabilitation significantly improves disease activity, function, and mobility in patients with axial spondyloarthritis, while a YouTube®-based exercise intervention failed to support such findings.

ZORYVE Seeks FDA Nod for Use in Children Ages 2–5

A new pediatric submission positions roflumilast cream as the first topical PDE4 inhibitor for children ages 2–5 with plaque psoriasis.

Subtyping Intestinal Metaplasia May Predict Gastric Cancer Risk

A new study supports the utility of subtyping intestinal metaplasia as a predictor of gastric cancer risk.

Gut Microbiota Modulation via FMT and Probiotics Promotes Hair Regrowth in Androgenetic Alopecia

New evidence links gut microbiota to androgenetic alopecia, with fecal microbiota transplantation and probiotics showing potential to restore hair growth through anti-inflammatory effects.

GNRI May Help to Identify Unresectable HCC Patients on Immunotherapy at High Risk for Immune-mediated Adverse Events

A new study reports that the Geriatric Nutritional Risk Index could be used to identify patients with unresectable hepatocellular carcinoma on immunotherapy at high risk for immune-mediated adverse events.

Inflammation, Gut Microbiota Dysfunction Contributes to CIA-related Sarcopenia

A new study reports that inflammation and gut microbiota dysfunction contributes to the pathogenesis of collagen-induced arthritis–related sarcopenia, adding that coix seed oil may be a potential therapeutic agent.

Adding Sintilimab to Capecitabine–Oxaliplatin Following Radiotherapy Improves the LARC Response Rate

A new study reports that adding sintilimab to capecitabine–oxaliplatin following radiotherapy improves the pathological complete response rate in patients with locally advanced rectal cancer, albeit with more postoperative complications.

Narirutin: Promising Therapeutic Drug Candidate in Inflammatory Arthritis

A new study suggests the potential of targeting macrophage pro-inflammatory M1 phenotype in and osteoclastogenesis as an effective strategy for inflammatory arthritis and systemic osteoporosis and positions narirutin as a promising therapeutic drug candidate.

Metabolic Disease May Affect Chronic Hepatitis B Response to Antivirals

A new study reports that the presence and number of metabolic diseases can influence the chronic Hepatitis B response to antiviral treatment.

Blood-based Test Shows "Acceptable" Accuracy for Colorectal Cancer Detection

A new study reports that a blood-based test demonstrated acceptable accuracy for colorectal cancer detection, although its detection of advanced precancerous lesions remains inadequate.

Risankizumab Safe, Effective in Crohn's Disease

A new study presents long-term real-world data suggesting the safety and effectiveness of risankizumab in Crohn's disease.

Knee OA Patients Show High Vitamin D Deficiency Prevalence

A new study reveals that vitamin D deficiency is highly prevalent in patients with knee osteoarthritis, especially those with bilateral OA and polyarthralgia.

Delgocitinib (ANZUPGO®) Now Available for Prescribing as First FDA-Approved Treatment for Chronic Hand Eczema

As of today, U.S. dermatologists can prescribe delgocitinib cream (ANZUPGO®), the first FDA-approved therapy for adults with moderate-to-severe chronic hand eczema.

No Significantly Increased Infection Risk with Combination Targeted Therapy in Psoriatic Arthritis

A new study found no significant difference between the incidence of serious bacterial and opportunistic infections requiring hospitalization in psoriatic arthritis patients receiving combination targeted therapy versus standard therapy.

Liver Transplantation after Downstaging Feasible in Patients who Exceed UNOS Criteria, Albeit with Need to Define Upper Limit

A new study reports that patients with hepatocellular carcinoma who exceed United Network for Organ Sharing downstaging criteria may still be candidates for liver transplantation.

Two-sample Fecal Immunochemical Testing Identifies Patients at High Risk for Colorectal Cancer

A new study concludes that the systemic immune–inflammation index and systemic inflammation response index both demonstrate relationships with osteoarthritis.

GLP-1 Receptor Agonists Show Promise as Adjunctive Therapy in Hidradenitis Suppurativa

A systematic review suggests GLP-1 receptor agonists may improve both metabolic health and disease activity in HS.

Firsekibart Superior to Etoricoxib for Joint Pain Relief in Patients Experiencing Frequent Gout Flares

A new study concludes that firsekibart outperforms etoricoxib for achieving target joint pain relief among patients experiencing frequent gout flares.

Ripretinib May Benefit Patients with Gastrointestinal Stromal Tumors Intolerant to Sunitinib

A new study suggests that patients with advanced gastrointestinal stromal tumors who experience disease progression on imatinib and sunitinib intolerance could be treated with ripretinib.

Antisense-mediated DGAT2 Inhibitor ION224 Safe, Effective in MASH

A new study concludes that ION224 may be a safe and effective therapeutic strategy for metabolic dysfunction–associated steatohepatitis.

No Survival Benefit Difference in MaB + Chemo vs. Chemo Alone in Gastric Cancer Patients with Low PD-L1 Expression

A new study has determined that the monoclonal antibodies to chemotherapy does not alter the survival benefit among patients with gastric cancer and low programmed death-ligand 1 expression.

New Guideline Comments on Hematopoietic Stem Cell Transplantation in Rheumatologic and Musculoskeletal Diseases

A new guideline offers updated recommendations for the use of hematopoietic stem cell transplantation in patients with rheumatologic and musculoskeletal diseases.

Apremilast Reduces Topical Steroid and Vitamin D Analogue Use in Psoriasis

A Japanese claims study shows apremilast reduces reliance on potent topical steroids and vitamin D analogues in psoriasis patients.

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Late Breakers

Top 5 Industry Updates

DecisionDx-SCC Improves Risk Stratification and Treatment Guidance in High-Risk Cutaneous SCC

Descriptive Analysis Further Supports Long-term Safety of Treating Chronic Diseases with Upadacitinib

Industry Information

DUPIXENT® (dupilumab) APPROVED FOR ANOTHER NEW INDICATION

Novel Risk Score Predicts Post-transplant Recurrence in Perihilar Cholangiocarcinoma

Industry Information

New Data Show 40-Gene Expression Profile (DecisionDx®-SCC) Identifies Cutaneous Squamous Cell Carcinoma Patients Most Likely to Benefit from Adjuvant Radiation Therapy

AI Assistance Improves GI Precancerous Lesion Detection Rates

Read More

Educational Video Intervention Fails to Improve Bowel Preparation for Colonoscopy Versus Written Instructions

Risk Levels for Hematologic, Solid Organ Cancers Increased Among Systemic Sclerosis Patients

Telerehabilitation Improves Disease Activity, Function, and Mobility in Axial Spondyloarthritis

ZORYVE Seeks FDA Nod for Use in Children Ages 2–5

Subtyping Intestinal Metaplasia May Predict Gastric Cancer Risk

Gut Microbiota Modulation via FMT and Probiotics Promotes Hair Regrowth in Androgenetic Alopecia

GNRI May Help to Identify Unresectable HCC Patients on Immunotherapy at High Risk for Immune-mediated Adverse Events

Inflammation, Gut Microbiota Dysfunction Contributes to CIA-related Sarcopenia

Adding Sintilimab to Capecitabine–Oxaliplatin Following Radiotherapy Improves the LARC Response Rate

Narirutin: Promising Therapeutic Drug Candidate in Inflammatory Arthritis

Metabolic Disease May Affect Chronic Hepatitis B Response to Antivirals

Blood-based Test Shows "Acceptable" Accuracy for Colorectal Cancer Detection

Risankizumab Safe, Effective in Crohn's Disease

Knee OA Patients Show High Vitamin D Deficiency Prevalence

Delgocitinib (ANZUPGO®) Now Available for Prescribing as First FDA-Approved Treatment for Chronic Hand Eczema

No Significantly Increased Infection Risk with Combination Targeted Therapy in Psoriatic Arthritis

Liver Transplantation after Downstaging Feasible in Patients who Exceed UNOS Criteria, Albeit with Need to Define Upper Limit

Two-sample Fecal Immunochemical Testing Identifies Patients at High Risk for Colorectal Cancer

GLP-1 Receptor Agonists Show Promise as Adjunctive Therapy in Hidradenitis Suppurativa

Firsekibart Superior to Etoricoxib for Joint Pain Relief in Patients Experiencing Frequent Gout Flares

Ripretinib May Benefit Patients with Gastrointestinal Stromal Tumors Intolerant to Sunitinib

Antisense-mediated DGAT2 Inhibitor ION224 Safe, Effective in MASH

No Survival Benefit Difference in MaB + Chemo vs. Chemo Alone in Gastric Cancer Patients with Low PD-L1 Expression

New Guideline Comments on Hematopoietic Stem Cell Transplantation in Rheumatologic and Musculoskeletal Diseases

Apremilast Reduces Topical Steroid and Vitamin D Analogue Use in Psoriasis