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Calcitriol

Brand and Other Names: VECTICAL
Mechanism of Action:
The mechanism of action of calcitriol in the treatment of psoriasis has not been established.
Indications:
VECTICAL Ointment is indicated for the topical treatment of mild to moderate plaque psoriasis in adults and pediatric patients 2 years and older.
Route: Topical
Dose:
Apply VECTICAL Ointment to affected areas of the body twice daily. Adults: The maximum weekly dose should not exceed 200 grams. Pediatrics: 2 to 6 years of age: The maximum weekly dose should not exceed 100 grams. 7 years of age and older: The maximum weekly dose should not exceed 200 grams.
Adverse Reactions:
Most common adverse reactions (incidence ≥ 3%) are hypercalcemia, hypercalciuria, and skin discomfort.
Contraindication:
None
Warnings and Precautions:
Effects on Calcium metabolism: Risk of hypercalcemia. If aberrations in parameters of calcium metabolism are noted discontinue VECTICAL Ointment until these normalize. Increased absorption may occur with occlusive use. VECTICAL Ointment should be used with caution in patients receiving medications known to increase the serum calcium level, such as thiazide diuretics, and in patients receiving calcium supplements or high doses of vitamin D.
See package insert for full prescribing information.