The mechanism of action of AMZEEQ for the treatment of acne is unknown.

AMZEEQ is indicated for the topical treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in adults and pediatric patients 9 years of age and older. Limitations of Use: This formulation of minocycline has not been evaluated in the treatment of infections. To reduce the development of drug-resistant bacteria as well as to maintain the effectiveness of other antibacterial drugs, AMZEEQ should be used only as indicated.

Topical foam, 4%. Apply AMZEEQ to affected areas once daily. AMZEEQ should be gently rubbed into the skin. (See Full Prescribing Information.)

The most common adverse reaction reported by ≥1% of subjects treated with AMZEEQ and more frequently than in subjects treated with vehicle was headache, which was reported in 3% of subjects treated with AMZEEQ and 2% of subjects treated with vehicle. (See Full Prescribing Information.)

This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines or any other ingredients within AMZEEQ.

The propellant in AMZEEQ is flammable. Instruct the patient to avoid fire, flame, and smoking during and immediately following application. Do not puncture and/or incinerate the containers. Do not expose containers to heat and/or store at temperatures above 120°F (49°C). Other precautions were listed at Teratogenic Effects, Tooth Discoloration, Inhibition of Bone Growth, Clostridioides difficile Associated Diarrhea, Hepatotoxicity, Metabolic Effects, Central Nervous System Effects, Intracranial Hypertension, Autoimmune Syndromes, Photosensitivity, Serious Skin/Hypersensitivity Reaction, Tissue Hyperpigmentation, Development of Drug-Resistant Bacteria, Superinfection/Potential for Microbial Overgrowth. (See Full Prescribing Information.)