Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components.

Nystatin Cream USP is indicated in the treatment of cutaneous or mucocutaneous mycotic infections caused by Candida albicans and other susceptible Candida species. Nystatin Cream USP is not indicated for systemic, oral, intravaginal or ophthalmic use.

Apply liberally to affected areas twice daily or as indicated until healing is complete.

The frequency of adverse events reported in patients using Nystatin Cream USP is less than 0.1%. The more common events that were reported include allergic reactions, burning, itching, rash, eczema, and pain on application (see PRECAUTIONS-General).

Nystatin Cream USP is contraindicated in patients with a history of hypersensitivity to any of its components.

Nystatin Cream USP should not be used for the treatment of systemic, oral, intravaginal or ophthalmic infections.