Cortenema is indicated as adjunctive therapy in the treatment of Ulcerative Colitis, especially distal forms, including Ulcerative Proctitis, Ulcer Proctosigmoiditis, and Left-Sided Ulcerative Colitis. It has proved useful also in some cases involving the transverse and ascending colon.

The usual course of therapy is one Cortenema nightly for 21 days, or until the patient comes into remission both clinically and proctologically. Clinical symptoms usually subside promptly within 3 to 5 days. Improvement in the appearance of the mucosa, as seen by sigmoidoscopic examination, may lag somewhat behind clinical improvement. See package insert for complete information.

Local pain or burning, and rectal bleeding attributed to Cortenema have been reported rarely. Apparent exacerbations or sensitivity reactions also occur rarely. The following adverse reactions should be kept in mind whenever corticosteroids are given by rectal administration.

Systemic fungal infections; and ileocolostomy during the immediate or early post-operative period.

Cortenema hydrocortisone retention enema should be used with caution where there is a probability of impending perforation, abscess, or other pyogenic infection; fresh intestinal anastomoses; obstruction; or extensive fistulas and sinus tract. Use with caution in the presence of active or latent peptic ulcer; diverticulitis; renal insufficiency; hypertension; osteoporosis; and myasthenia gravis. See package insert for complete information.