Scopolamine, a belladonna alkaloid, is an anticholinergic agent. Scopolamine acts: i) as a competitive inhibitor at postganglionic muscarinic receptor sites of the parasympathetic nervous system, and ii) on smooth muscles that respond to acetylcholine but lack cholinergic innervation. It has been suggested that scopolamine acts in the central nervous system (CNS) by blocking cholinergic transmission from the vestibular nuclei to higher centers in the CNS and from the reticular formation to the vomiting center. Scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function.

Transderm Scōp is an anticholinergic agent indicated in adults for the prevention of nausea and vomiting associated with:
•Motion Sickness
•Post Operative Nausea and Vomiting (PONV)

Motion Sickness:
•Apply 4 hrs before antiemetic effect is required- for use up to 3 days
•For use longer than 3 days, remove current patch an place new patch behind other ear Post Operative Nausea and Vomiting (PONV) : •Apply evening before scheduled surgery.
•For cesarean section, apply 1 hour prior to surgery.
• Discard 24 hrs after surgery.

Most common adverse reactions during motion sickness clinical trials are dry mouth, drowsiness and blurred vision. Most common adverse reactions during PONV trials (≥ than 3%) are dry mouth, dizziness, somnolence, urinary retention, agitation, visual impairment, confusion, mydriasis and pharyngitis.

•Patients with angle closure glaucoma (4, 6.2)
•Persons who are hypersensitive to scopolamine or to other belladonna alkaloids

•Use with caution in patients with open angle glaucoma.
•Stop use if patient experiences symptoms of angle closure glaucoma.
•Can cause temporary dilation and blurred vision if scopolamine contacts the eyes.
•Use caution in patients with a history of seizures or psychosis.
•Use with caution in patients with pyloric obstruction, urinary bladder neck obstruction, or patients suspected of having intestinal obstruction. See package insert for complete information.