Corticosteroids play a role in cellular signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action of Fluocinonide Cream in corticosteroid responsive dermatoses is unknown.

Fluocinonide Cream is indicated for:

Corticosteroid-responsive dermatoses

• Psoriasis
• Atopic dermatitis
• Other inflammatory skin conditions

Psoriasis: Apply thin layer once or twice daily

Atopic Dermatitis: Apply thin layer once daily

Other dermatoses: Apply once or twice daily as directed

Common clinical trial adverse effects (≥1%):

• Headache (3.7–4%)
• Application site burning (1.8–2.3%)
• Nasopharyngitis (0.9–1.3%)
• Nasal congestion

None

Endocrine Effects:

• May suppress HPA axis, causing adrenal insufficiency
• Can result in Cushing’s syndrome, hyperglycemia, and unmasking of latent diabetes

Local Skin Reactions:

• Potential for atrophy, striae, hypopigmentation, acneiform eruptions, and irritation
• Higher risk with prolonged use or occlusion

Infections:

• Secondary infections may require antifungal/antibacterial treatment
• Discontinue if infection persists

Allergic Contact Dermatitis:

• Diagnose through lack of healing
• May require patch testing