Etoposide
Brand and Other Names:
Etoposide
Mechanism of Action:
Etoposide acts mainly at the G2 phase of the cell cycle, inhibiting cells from entering mitosis. It induces DNA strand breaks via interaction with topoisomerase II.
Indications:
Indicated for th treatment of small cell lung cancer (SCLC) in combination with other chemotherapeutics as first-line therapy.
Route:
oral
Dose:
Typically twice the IV dose, rounded to the nearest 50 mg.
Adverse Reactions:
- Leukopenia
- Thrombocytopenia
- Anemia
- Nausea/Vomiting
- Alopecia
- Hypotension (IV only)
- Allergic Reactions
Contraindication:
Etoposide capsules are contraindicated in patients who have demonstrated a previous hypersensitivity to etoposide or any component of the formulation.
Warnings and Precautions:
- Myelosuppression
- Pregnancy
- Carcinogenicity
- Renal Impairmen
See package insert for full prescribing information.