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prednisolone acetate

Brand and Other Names: PRED FORTE
Mechanism of Action:

Glucocorticoids inhibit the edema, fibrin deposition, capillary dilation, and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen, and scar formation.

Indications:

Used to treat steroid-responsive inflammation of:

  • Palpebral and bulbar conjunctiva
  • Cornea
  • Anterior segment of the globe
Route: topical
Dose:

1–2 drops into the conjunctival sac 2–4 times daily

Adverse Reactions:

Common:

  • Elevated IOP
  • Cataract formation
  • Delayed healing

Less common:

  • Infections (bacterial, fungal, viral)
  • Ocular irritation (burning, stinging, blurry vision)
  • Allergic reactions, eye pain, pruritus
  • Rare: uveitis, optic nerve damage, corneal ulcers, mydriasis, ptosis
Contraindication:

Active untreated purulent ocular infections

Most viral eye diseases (e.g., herpes simplex, vaccinia, varicella)

Mycobacterial or fungal eye infections

Known hypersensitivity to ingredients or corticosteroids

Warnings and Precautions:

Prolonged use risks:

  • Posterior subcapsular cataracts
  • Elevated intraocular pressure → glaucoma
  • Suppressed immune response → secondary infections
  • Delayed wound healing, especially post-cataract surgery

Use with caution in glaucoma, herpes simplex history, or thin corneal/scleral tissue

Contains sodium bisulfite, a potential allergen (especially in asthmatics)

See package insert for full prescribing information.