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hepatitis a and hepatitis b- recombinant vaccine injection

Brand and Other Names: Twinrix
Mechanism of Action:

The presence of antibodies to HAV (anti-HAV) confers protection against hepatitis A disease.

Antibody concentrations ≥10 mIU/mL against HBsAg are recognized as conferring protection against hepatitis B virus infection.4

Indications:

Active immunization against:

  • Hepatitis A virus
  • All known subtypes of hepatitis B virus
Route: intramuscular
Dose:

Standard dosing: 3 doses (1 mL each) at 0, 1, and 6 months

Accelerated dosing: 4 doses (1 mL each) on Days 0, 7, and 21–30, followed by a booster at Month 12

Adverse Reactions:

Injection site:

  • Soreness (35–41%)

  • Redness (8–11%)

Systemic:

  • Headache (13–22%)

  • Fatigue (11–14%)

Contraindication:

Severe allergic reaction (e.g., anaphylaxis) to:

  • Previous hepatitis A/B vaccine

  • Yeast, neomycin, or other components of TWINRIX

Warnings and Precautions:

Syncope may occur—take measures to prevent injury

Postpone vaccination during moderate/severe acute febrile illness

Effectiveness may be reduced in immunocompromised individuals

TWINRIX does not prevent infection in individuals already infected

See package insert for full prescribing information.