CMV Retinitis in AIDS patients

Mucocutaneous Acyclovir-Resistant HSV Infections in immunocompromised individuals

CMV: 60 mg/kg every 8h or 90 mg/kg every 12h for 2–3 weeks

HSV: 40 mg/kg every 8–12h until lesions heal

Most common: Fever (65%), nausea (47%), anemia (33%), diarrhea (30%), abnormal renal function (27%), seizures (10%)

Severe AEs: Death (14%), renal dysfunction (14%), marrow suppression (10%)

Post-marketing reports: Nephrotic syndrome, glomerulonephritis, QT prolongation, Fanconi syndrome, and rare dermatologic reactions like Stevens-Johnson syndrome

Foscarnet sodium injection is contraindicated in patients with clinically significant hypersensitivity to foscarnet sodium.

Renal Impairment: The most serious toxicity. Requires close monitoring of serum creatinine and creatinine clearance.

Seizures: May occur due to electrolyte imbalances, especially hypocalcemia.

Electrolyte Disturbances: Includes hypocalcemia, hypokalemia, hypomagnesemia, and more.

QT Prolongation and Torsades de Pointes: Risk increases with existing cardiac conditions or electrolyte issues.

Hypersensitivity Reactions: Including anaphylaxis, angioedema.