afamelanotide implant
Brand and Other Names:
SCENESSE
Mechanism of Action:
Afamelanotide increases eumelanin production independent of UV exposure.
Indications:
SCENESSE ® is indicated to increase pain free light exposure in adult patients with a history of phototoxic reactions from erythropoietic protoporphyria (EPP).
Route:
subcutaneous
Dose:
Route: Subcutaneous implant every 2 months.
Location: Insert above the anterior supra-iliac crest.
Adverse Reactions:
Implant site reaction (21%)
Nausea (19%)
Oropharyngeal pain (7%)
Fatigue, dizziness, somnolence
Skin hyperpigmentation (4%)
Melanocytic nevus
Respiratory tract infection
Contraindication:
Contraindicated in patients with severe hypersensitivity to afamelanotide or its excipients.
Warnings and Precautions:
Serious hypersensitivity reactions (including anaphylaxis) reported.
Skin pigmentation changes (including darkening of nevi and ephelides) may occur.
See package insert for full prescribing information.