Acotiamide
Brand and Other Names:
Acotiamide
Mechanism of Action:
Indications:
Route:
Dose:
Adverse Reactions:
Contraindication:
Warnings and Precautions:
Approved in Japan; investigational in U.S./EU
GOOGLE OVERVIEW
Acotiamide, also known by the brand names Acofide and Dyspevict, is a medication approved in Japan and Russia for treating functional dyspepsia.
Here's a breakdown of what you should know about acotiamide:
Uses
- Acotiamide is primarily used to relieve symptoms associated with functional dyspepsia, a chronic digestive disorder.
- It effectively reduces postprandial fullness (feeling full after eating), upper abdominal bloating, and early satiety (feeling full after consuming only a small amount of food).
Mechanism of action
- Acotiamide acts as an acetylcholinesterase inhibitor.
- It works by blocking muscarinic receptors and inhibiting acetylcholinesterase, which in turn increases the levels of acetylcholine in the stomach.
- This enhanced acetylcholine release improves impaired gastric motility (the movement of food through the digestive tract) and accelerates gastric emptying.
Dosage
- For extended-release tablets, the typical dosage is 300 mg once daily before meals.
- For immediate-release tablets, the usual dosage is 100 mg three times daily before meals.
- It's important to complete the entire course of treatment as prescribed by your doctor, even if your symptoms improve sooner.
Side effects
- Common side effects include diarrhea, constipation, nausea, vomiting, rashes, headaches, and abdominal pain.
- Serious side effects are rare but can include severe allergic reactions or intense abdominal pain, according to Steris Online.
- Consult your doctor if you experience any concerning side effects or if they persist.
Precautions
- Inform your doctor if you are allergic to acotiamide or any of its components.
- Disclose any other medical conditions or medications you are taking to avoid potential drug interactions.
- Discuss the use of acotiamide with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
- Avoid consuming alcohol while taking acotiamide as the interaction is unknown.
Interactions
- Acotiamide can interact with anticholinergic drugs, potentially reducing its effectiveness.
- Avoid using it in patients with gastrointestinal hemorrhage.
Availability
- Acotiamide is currently approved for use in Japan and Russia.
- Clinical trials have been conducted in the United States and Europe, but it's not yet approved in those regions for general use.
Note: This information is for general knowledge and should not be considered medical advice. Always consult with a healthcare professional before starting any new medication.
See package insert for full prescribing information.