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Acotiamide

Brand and Other Names: Acotiamide
Mechanism of Action:
Indications:
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Description:

Approved in Japan; investigational in U.S./EU

GOOGLE OVERVIEW

Acotiamide, also known by the brand names Acofide and Dyspevict, is a medication approved in Japan and Russia for treating functional dyspepsia. 
 
Here's a breakdown of what you should know about acotiamide:
Uses
  • Acotiamide is primarily used to relieve symptoms associated with functional dyspepsia, a chronic digestive disorder.
  • It effectively reduces postprandial fullness (feeling full after eating), upper abdominal bloating, and early satiety (feeling full after consuming only a small amount of food). 
Mechanism of action
  • Acotiamide acts as an acetylcholinesterase inhibitor.
  • It works by blocking muscarinic receptors and inhibiting acetylcholinesterase, which in turn increases the levels of acetylcholine in the stomach.
  • This enhanced acetylcholine release improves impaired gastric motility (the movement of food through the digestive tract) and accelerates gastric emptying. 
Dosage
  • For extended-release tablets, the typical dosage is 300 mg once daily before meals.
  • For immediate-release tablets, the usual dosage is 100 mg three times daily before meals.
  • It's important to complete the entire course of treatment as prescribed by your doctor, even if your symptoms improve sooner. 
Side effects
  • Common side effects include diarrhea, constipation, nausea, vomiting, rashes, headaches, and abdominal pain.
  • Serious side effects are rare but can include severe allergic reactions or intense abdominal pain, according to Steris Online.
  • Consult your doctor if you experience any concerning side effects or if they persist. 
Precautions
  • Inform your doctor if you are allergic to acotiamide or any of its components.
  • Disclose any other medical conditions or medications you are taking to avoid potential drug interactions.
  • Discuss the use of acotiamide with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Avoid consuming alcohol while taking acotiamide as the interaction is unknown. 
Interactions
  • Acotiamide can interact with anticholinergic drugs, potentially reducing its effectiveness.
  • Avoid using it in patients with gastrointestinal hemorrhage. 
Availability
  • Acotiamide is currently approved for use in Japan and Russia.
  • Clinical trials have been conducted in the United States and Europe, but it's not yet approved in those regions for general use. 
Note: This information is for general knowledge and should not be considered medical advice. Always consult with a healthcare professional before starting any new medication.
See package insert for full prescribing information.