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Ad26.ZEBOV-GP

Brand and Other Names: Zabdeno
Mechanism of Action:
Indications:
Route:
Dose:
Adverse Reactions:
Contraindication:
Warnings and Precautions:
Description:

Not FDA-approved in the US; approved in EU in July 2020 (European Medicines Agency (EMA)) 

GOOGLE OVERVIEW

Ad26.ZEBOV-GP, also known as Zabdeno, is a recombinant adenovirus serotype 26 (Ad26) vector-based vaccine used to protect against Ebola virus disease. It is a component of a two-dose regimen, alongside MVA-BN-Filo, and is administered intramuscularly. The vaccine encodes the glycoprotein (GP) of the Zaire ebolavirus, specifically the Mayinga strain. 
 
Here's a more detailed explanation:
  • Adenovirus Vector:
    Ad26.ZEBOV-GP utilizes a weakened adenovirus (Ad26) as a vector to deliver the Ebola virus glycoprotein into the body. 
     
  • Glycoprotein (GP) Antigen:
    The vaccine contains the gene for the Ebola virus GP, which is a key protein that the virus uses to enter cells. By triggering an immune response against this protein, the vaccine aims to prepare the body to fight off future infections. 
     
  • Two-Dose Regimen:
    Ad26.ZEBOV-GP is typically given as the first dose in a two-dose regimen, followed by MVA-BN-Filo. 
     
  • Intramuscular Injection:
    The vaccine is administered as a 0.5 mL liquid suspension into the muscle, usually the deltoid muscle of the upper arm. 
     
  • No Adjuvant:
    Zabdeno does not contain any adjuvant, which are substances that can boost the immune response. 
     
  • Safety and Immunogenicity:
    Studies have shown that the Ad26.ZEBOV-GP, MVA-BN-Filo regimen is generally safe and elicits a strong immune response against the Ebola virus. 
     
 

 

See package insert for full prescribing information.