Azithromycin is a macrolide antibacterial drug.

ZITHROMAX is a macrolide antibacterial drug indicated for mild to moderate infections caused by designated, susceptible bacteria: Acute bacterial exacerbations of chronic bronchitis in adults, Acute bacterial sinusitis in adults, Uncomplicated skin and skin structure infections in adults, Urethritis and cervicitis in adults, Genital ulcer disease in men, Acute otitis media in pediatric patients (6 months of age and older), Community-acquired pneumonia in adults and pediatric patients (6 months of age and older), Pharyngitis/tonsillitis in adults and pediatric patients (2 years of age and older)

Skin/skin structure (uncomplicated): 500 mg as a single dose on Day 1, followed by 250 mg once daily on Days 2 through 5. (See Full Prescribing Information.)

Most common adverse reactions are diarrhea (5 to 14%), nausea (3 to 18%), abdominal pain (3 to 7%), or vomiting (2 to 7%).

Patients with known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide drug. Patients with a history of cholestatic jaundice/hepatic dysfunction associated with prior use of azithromycin.

Serious (including fatal) allergic and skin reactions: Discontinue ZITHROMAX if reaction occurs. Hepatotoxicity: Severe, and sometimes fatal, hepatotoxicity has been reported. Discontinue ZITHROMAX immediately if signs and symptoms of hepatitis occur. Infantile Hypertrophic Pyloric Stenosis (IHPS): Following the use of azithromycin in neonates (treatment up to 42 days of life), IHPS has been reported. Direct parents and caregivers to contact their physician if vomiting or irritability with feeding occurs. Prolongation of QT interval and cases of torsades de pointes have been reported. This risk which can be fatal should be considered in patients with certain cardiovascular disorders including known QT prolongation or history torsades de pointes, those with proarrhythmic conditions, and with other drugs that prolong the QT interval. Clostridium difficile-Associated Diarrhea: Evaluate patients if diarrhea occurs. ZITHROMAX may exacerbate muscle weakness in persons with myasthenia gravis.