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AIH and PBC

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AIH and PBC- Case 1

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AIH and PBC- Case 2

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AIH and PBC - Case 3

1. What is the primary marker for Type 1 Autoimmune Hepatitis (AIH)?

Select only 1 answer.

  1. A. Anti-LKM antibody
  2. B. Anti-smooth muscle antibody (ASMA)
  3. C. Anti-mitochondrial antibody (AMA)
  4. D. Anti-SLA antibody

2. Which age group has the highest incidence of Autoimmune Hepatitis?

Select only 1 answer.

  1. A. Children under 10 years
  2. B. Adolescents
  3. C. Adults in their 20s and 60s-70s
  4. D. Adults over 80 years

3. What percentage of patients with AIH are female?

Select only 1 answer.

  1. A. 10-20%
  2. B. 30-40%
  3. C. 50-60%
  4. D. 70-95%

4. Which antibody is commonly found in Primary Biliary Cholangitis (PBC)?

Select only 1 answer.

  1. A. ANA
  2. B. ASMA
  3. C. Anti-LKM antibody
  4. D. AMA

5. What is the typical initial treatment for Autoimmune Hepatitis?

Select only 1 answer.

  1. A. Ursodeoxycholic acid
  2. B. Prednisone
  3. C. Mycophenolate mofetil
  4. D. Methotrexate

6. What is the most common symptom of Primary Biliary Cholangitis?

Select only 1 answer.

  1. A. Abdominal pain
  2. B. Fatigue
  3. C. Jaundice
  4. D. Pruritus

7. Which of the following is a recommended treatment for pruritus in PBC?

Select only 1 answer.

  1. A. Prednisone
  2. B. Cholestyramine
  3. C. Methotrexate
  4. D. Azathioprine

8. Which histological feature differentiates AIH from other liver diseases?

Select only 1 answer.

  1. A. Steatosis
  2. B. Lobular hepatitis
  3. C. Interface hepatitis
  4. D. Perivenulitis

9. In AIH, which condition is most likely to present concomitantly?

Select only 1 answer.

  1. A. Celiac disease
  2. B. Rheumatoid arthritis
  3. C. Systemic lupus erythematosus (SLE)
  4. D. Hashimoto's thyroiditis

10. Which drug is contraindicated in the treatment of PBC with advanced cirrhosis?

Select only 1 answer.

  1. A. Ursodeoxycholic acid
  2. B. Prednisone
  3. C. Obeticholic acid
  4. D. Methotrexate

11. Which of the following is true regarding the use of azathioprine in AIH?

Select only 1 answer.

  1. A. It is used as the initial treatment.
  2. B. It is contraindicated in patients with decompensated cirrhosis.
  3. C. It does not require monitoring for cytopenia.
  4. D. It is safe to use in pregnancy.

12. Which factor is associated with a higher likelihood of achieving complete biochemical remission in AIH?

Select only 1 answer.

  1. A. Presence of cirrhosis
  2. B. Older age
  3. C. Faster ALT decline
  4. D. Higher baseline IgG

13. What is the role of liver biopsy in diagnosing PBC?

Select only 1 answer.

  1. A. It is mandatory for all cases.
  2. B. It is only needed if AMA is negative or clinical picture is unclear.
  3. C. It is never needed.
  4. D. It is used to monitor treatment response.

14. Which treatment is NOT typically used for pruritus in PBC?

Select only 1 answer.

  1. A. Cholestyramine
  2. B. Rifampicin
  3. C. Sertraline
  4. D. Azathioprine

15. What is the treatment goal for AIH?

Select only 1 answer.

  1. A. Reduction of symptoms
  2. B. Normalization of AST, ALT, and IgG
  3. C. Prevention of cirrhosis
  4. D. Minimizing side effects of medication

16. What is the recommended course of action for a patient with AIH who has relapsed after stopping immunosuppressive therapy?

Select only 1 answer.

  1. A. Restart prednisone and azathioprine
  2. B. Observe and monitor
  3. C. Start methotrexate
  4. D. Initiate rituximab

17. What is a key predictor of response to treatment in PBC?

Select only 1 answer.

  1. A. Initial bilirubin level
  2. B. Reduction in alkaline phosphatase
  3. C. Presence of AMA
  4. D. Degree of fibrosis on biopsy